Research Watch, COLUMNS-Silica, October 2004

photo-1 Recent Silica-Related Research Published in Medical Journals Around the Globe

Signaling Pathways Controlling the Production of Inflammatory Mediators in Response to Crystalline
Silica Exposure: Role of Reactive Oxygen/ Nitrogen Species

Journal: Free Radical Biology & Medicine 2004 Oct.1;37(7):916-25

Author: V. Castranova

photo-2Summary: The author states, following a statement that occupational exposure to silica has been linked to pulmonary fibrosis and lung cancer, that the surface properties of crystalline silica are critical to the production of oxidants, fibroblast activation and disease. The review summarizes evidence that in vitro and in vivo exposure to crystalline silica results in …