Research Watch

A Biphasic Response to Silica. I. Immunostimulation Is Restricted to the Early Stage of Silicosis

Journal: American Journal of Respiratory Cell and Molecular Biology 2004 Jan 23 (e-publication)

Authors: R.J. Langley, R. Kalra, N.C. Mishra, F.F. Hahn, S. Razani-Boroujerdi, S.P. Singh, J.M. Benson, J.C. Pena-Philippides, E.B. Barr, M.L. Sopori

photo-1To determine the immunological effects of silicosis, the researchers exposed rats to filtered air or silica at an exposure concentration of 6.2 mg/m3 for six hours a day, five days a week for six weeks and observed the animals up to 27 weeks after exposure. At two distinct stages - …