Abstracts from the Literature, LItigation Watch: Welding Rods, July 2005

AUTHORS: Crossgrove JS, Yokel RA. JOURNAL: Neurotoxicology. 2005 Jun;26(3):297-307. Epub 2005 Nov 11. SUMMARY: Manganese (Mn) is a required co-factor for many ubiquitous enzymes; however, chronic Mn overexposure can cause manganism, a parkinsonian-like syndrome. Overall these results suggest that both Ca-dependent and Ca-independent mechanisms play a role in brain Mn influx. This work provides evidence that store-operated Ca channels, as well as another mechanism at the blood-brain barrier, likely play a role in carrier-mediated Mn influx into …