Pulmonary Reponse of Rats to Crystalline Silica:
Report On a Unique Six-Month Study





photo-6In recent months, Dr. Dale Porter, Dr. Vincent Castranova and their co-authors have published a series of articles1-4 on conclusions drawn from a chronic inhalation study of silica using rats. (See Summary Review at the end of this article.) What makes their study different from other acute, bolus exposure studies is its long-term nature and relatively low-level silica exposures.

Dr. Castranova, who has a Ph.D. in Physiology from West Virginia University and is a Branch Chief, Chief of the Pathology and Physiology Research Branch, in the Health Effects Laboratory Division at The National Institute for Occupational …






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