Research Watch, Arthritis Drugs, December 2006

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Stronger Inhibition by Nonsteroid Anti-Inflammatory Drugs of Cyclooxygenase-1 in Endothelial Cells than Platelets Offers an Explanation for Increased Risk of Thrombotic Events

Journal: The FASEB Journal 2006 Dec;20(14):2468-75

Authors: Mitchell JA, Lucas R, Vojnovic I, Hasan K, Pepper JR, Warner TD

Summary: Recent data have suggested that regular consumption of NSAIDs, particularly selective inhibitors of COX-2, is associated with an increased risk of thrombotic events. It has been suggested that this is due to NSAIDs reducing the release from the endothelium of the antithrombotic mediator prostaglandin I2 as a result of inhibition of endothelial COX-2. …