Research Watch, Arthritis Drugs, April 2007

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ARTICLE: 'Risk of Congestive Heart Failure with Nonsteroidal Antiinflammatory Drugs and Selective Cyclooxygenase 2 Inhibitors: A Class Effect?'

JOURNAL: Arthritis and Rheumatism 2007 Mar 29;57(3):516-523 [Epub ahead of print]

SUMMARY: NSAIDs as a class have been shown to increase the risk of congestive heart failure (CHF) compared with celecoxib, but the magnitude of the risk for individual NSAIDs is not known. This nested case-control study in a population-based cohort of patients ages >/=66 years found that indomethacin and rofecoxib are associated with a greater risk of recurrent CHF compared with celecoxib. There was no difference between …