Journal Watch, COLUMNS-Arthritis Drugs, April 2005

Blood Pressure in Native Americans Switched from Celecoxib to Rofecoxib (May)

Journal: Annals of Pharmacotherapy. 2005 Mar 29 [Epub]

Authors: J. Fredy, D.A. Diggins Jr., G. B. Morrill

Summary: This study sought to evaluate the effect of a formulary change from Celebrex to Vioxx on the blood pressure of Native American patients at a medical center in Arizona. Differences in the systolic and diastolic blood pressure before and after the therapy change were evaluated using a paired Student's t-test. A subgroup of patients with preexisting hypertension was also analyzed. The study revealed that during Vioxx therapy the mean systolic blood …