Journal Watch, Arthritis Drugs, October 2006

1 Nonsteroidal Antiinflammatory Drugs and Acute Myocardial Infarction in Patients with No Major Risk Factors

Journal: Pharmacotherapy 2006 Oct; 26(10):1379-87

Authors: Jick H, Kaye JA, Russmann S, Jick SS

Summary: The study objective was to assess the risk of long-term use of five nonsteroidal antiinflammatory drugs (NSAIDs)-rofecoxib, celecoxib, ibuprofen, naproxen, and diclofenac-in relation to acute myocardial infarction. The design included five separate nested case-control studies, one for each NSAID, designed to minimize important biases present in other observational studies. We identified people aged 30-79 years who had a first recorded prescription for rofecoxib, celecoxib, ibuprofen, naproxen, …