Abstracts From the Literature

Drug: Celebrex Article: Celecoxib Associated Esophagitis: Review of Gastrointestinal Side Effects from COX-2 Inhibitors Journal: Journal of Clinical Gastroenterology, 2003 Jul; 37(1): 61-3 Authors: P. Mantry, A. Shah, U. Sundaram

Summary: The authors report an 87-year-old man with chronic peptic esophageal stricture who experienced difficulty swallowing after taking Celebrex for five months. An upper endoscopy revealed that the patient developed severe desquamative esophagitis. The patient's symptoms improved after discontinuing the use of Celebrex for one month. After three months, an EGD revealed complete healing of the esophageal mucosa. The researchers stated that extensive use of COX-2 inhibitors such as …