Arthritis Drugs in the Medical Literature This Month - March 2007

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ARTICLE: 'The Effects of COX-2 Selective and Non-Selective NSAIDs on the Initiation and Progression of Atherosclerosis in ApoE(-/-) Mice'

JOURNAL: Journal of Molecular Medicine 2007 Feb 22; [Epub ahead of print]

SUMMARY: ApoE(-/-) mice, as well as corresponding wild-type mice, were fed either a normal chow or a high fat Western diet with or without addition of celecoxib, rofecoxib or naproxen over a period of 16 weeks. Results showed that neither the COX-2 selective inhibitors nor naproxen had a significant impact on the initiation and progression of atherosclerosis in diet-fed ApoE(-/-) mice, although both celecoxib and …