Journal Top Ten -- COLUMNS-Drugs & Supplements -- December 2006

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Crestor

ARTICLE: 'Efficacy and Safety of Rosuvastatin Every Other Day Compared with Once Daily in Patients with Hypercholesterolemia'

JOURNAL: The Annals of Pharmacotherapy 2006 Nov;40(11):1917-23.

SUMMARY: Although most patients with hypercholesterolemia require life-long therapy with statins, these drugs are underused due to high costs. Every-other-day therapy could be one strategy to resolve this problem without a major decrease in therapeutic benefit or increase in adverse events, in patients with hypercholesterolemia. The number of patients achieving their low-density lipoprotein cholesterol goal using the every-other-day regimen in this study was comparable with the number using the once-daily regimen, …