Journal Top Ten -- COLUMNS-Drugs & Supplements --August 2006

1 ARTICLE: 'Cognitive effects of lamotrigine compared with topiramate in patients with epilepsy'

JOURNAL: Neurology. 2006;67:400-406.

SUMMARY: The authors sought to compare the cognitive effects of lamotrigine versus topiramate as adjunctive therapy in adults with epilepsy. The study consisted of a multicenter, double-blind, randomized, prospective study conducted in adults with partial seizures. Lamotrigine or topiramate was introduced as an adjunctive therapy to carbamazepine or phenytoin and titrated over eight weeks to target doses. These drugs were maintained another eight weeks (maintenance phase) without dosage changes. On the individual cognitive tests, performance was better with lamotrigine …