Journal Top Ten, Columns-Drugs & Supplements, February 2006

ARTICLE: 'Conjugated Equine Estrogens and Coronary Heart Disease'

JOURNAL: Archives of Internal Medicine. 2006;166:357-365.

BACKGROUND: In recent randomized trials, conjugated equine estrogens with continuous medroxyprogesterone acetate provided no protection against coronary heart disease in postmenopausal women and may have increased cardiac risk. These trials did not address the role of unopposed estrogen for coronary protection.

METHODS: A total of 10,739 women aged 50 to 79 years at baseline (mean age, 63.6 years) who had previously undergone hysterectomy were randomized to receive CEE, 0.625 mg/d, or placebo at 40 …