Journal Top Ten -- COLUMNS-Drugs & Supplements -- April 2006

ARTICLE: 'Effects of Conjugated Equine Estrogens on Breast Cancer and Mammography Screening in Postmenopausal Women With Hysterectomy'

JOURNAL: Journal of the American Medical Association. 2006;295:1647-1657.

SUMMARY: The Women's Health Initiative Estrogen-Alone trial comparing conjugated equine estrogens with placebo was stopped early because of an increased stroke incidence and no reduction in risk of coronary heart disease. The objectice was to determine the effects of CEE on breast cancers and mammographic findings. 10,739 postmenopausal women aged 50 to 79 years with prior hysterectomy were randomized to CEE or placebo at 40 …