Journal Top Ten -- COLUMNS-Drugs & Supplements -- June 2006

ARTICLE: 'Major Congenital Malformations after First-Trimester Exposure to ACE Inhibitors'

JOURNAL: New England Journal of Medicine. Volume 354:2443-2451, June 8, 2006, Number 23

SUMMARY: The authors conducted a study to assess the association between exposure to angiotensin-converting-enzyme (ACE) inhibitors during the first trimester of pregnancy only and the risk of congenital malformations. They studied a cohort of 29,507 infants enrolled in Tennessee Medicaid and born between 1985 and 2000 for whom there was no evidence of maternal diabetes. They identified 209 infants with exposure to ACE inhibitors in the first trimester …