Journal Top Ten -- COLUMNS-Drugs & Supplements -- February 2004

1 Related Drug: Serzone

Article: Comparative CYP3A4 Inhibitory Effects of Venlaxafine, Fluoxetine, Sertraline, and Nefazodone in Healthy Volunteers

Summary: The authors state that in order for a patient receiving an antidepressant as well as another drug to avoid a potential drug-drug interaction, the antidepressant should not have an inhibitory or inductive effect on cytochrome CYP3A4. A four-way crossover study designed to investigate the potential of four diverse antidepressants to inhibit or induce CYP3A4 enzyme. Sixteen patients received clinically relevant doses of either venlaxafine (Effexor, Wyeth), nefazodone (Serzone, Bristol-Myers Squibb), sertraline (Zoloft, Pfizer) for eight days or fluoxetine …