Journal Top Ten - June 2003

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1 RELATED DRUG: Enbrel/Remicade

ARTICLE: Case Reports of Heart Failure After Therapy with a Tumor Necrosis Factor Antagonist

SUMMARY: A cases series involving 47 patients who experienced new or worsening heart failure during treatment with tumor necrosis factor (TNF) antagonists. Nineteen of the 38 patients who developed new-onset heart failure had no identifiable risk factors for heart failure and ten patients were under 50 years of age. Following the discontinuation of TNF antagonist therapy, the ten patients were administered treatments for heart failure. As a result, three patients experienced complete resolution, six patients improved, and one …