Journal Top Ten - January 2003

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1 RELATED DRUG: Celebrex
ARTICLE: Acute Cholestatic Hepatitis Associated with Celebrex SUMMARY: The report of a 41-year-old man who was hospitalized with jaundice after two doses of celcoxib 200 mg for the treatment of right knee trauma. The patient's laboratory results revealed mildly elevated serum transaminase concentrations and cholestasis. In addition, the patient's histology found evidence highly suggestive of drug-induced cholestasis. This is the first case report of an individual who developed cholestasis as a result of Celebrex ingestion and denied the use of alcohol, other drugs or herbs at the time of …