Journal Watch, COLUMNS-Drugs & Supplements, April 2007

1

Permax, Dostinex

ARTICLE: 'Assessment of Valvulopathy in Parkinson's Disease Patients on Pergolide and/or Cabergoline'

JOURNAL: Clinical Neurology and Neurosurgery 2007 May;109(4):350-3. Epub 2007 Feb 20

SUMMARY: The study assessed the effect of ergot derivatives on cardiac valves in patients with Parkinson's disease (PD). Moderate regurgitation in all three valves was significantly more common in the PD group than the controls. Severe valvular regurgitation was not observed in either group, with the exception of one PD patient. The frequency of valvulopathy and doses of agonists did not differ between groups that used either pergolide or cabergoline or …