Journal Top Ten -- COLUMNS-Drugs & Supplements -- March 2007

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Zyprexa/Seroquel

ARTICLE: 'A Clinical Study of the Association of Antipsychotics with Hyperlipidemia'

JOURNAL: Schizophrenia Research 2007 Mar 7; [Epub ahead of print]

SUMMARY: This study is consistent with emerging literature that suggests that some antipsychotics may have direct and immediate effects on lipid levels beyond obesity effects. Patients were divided into three groups: 57 on olanzapine, 105 on quetiapine, and 198 on other antipsychotics (risperidone, ziprasidone, aripiprazole or typicals). HDL and glucose levels were not significantly different across the three antipsychotic groups. When compared with other antipsychotics, olanzapine patients had a borderline significantly higher mean total …