Journal Top Ten -- COLUMNS-Mold -- April 2008

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ARTICLE: "Orbital and cranial nerve presentations and sequelae are hallmarks of invasive fungal sinusitis caused by Mucor in contrast to Aspergillus"

SUMMARY: Acute fulminant invasive fungal sinusitis is a rapidly progressing, destructive process almost exclusively affecting immunocompromised patients. Outcome differences have been found in patients with Mucor and Aspergillus. The authors performed this study to compare the presenting symptoms and long-term morbidity with IFS caused by Mucor versus Aspergillus species. Retrospective chart review was performed of 48 patients with 49 cases of acute fulminant IFS over a 19-year period. Long-term orbital and cranial nerve sequelae occurred in …