Journal Top Ten - February 2003
January 29, 2003
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1 ARTICLE: "Effects of the Mycotoxin Ochratoxin A and Some of Its Metabolites on the Human Cell Line THP-1"
SUMMARY: The authors describe the immunomodulatory effects of ochratoxin A and some of its metabolites on the human monocyte/macrophage line THP-1. The authors found that, at certain concentrations, these mycotoxins largely suppressed metabolic activity, cell proliferation, cell membrane integrity, cell differentiation, phagocytic behavior, nitrogen oxide synthesis and cell surface markers. Ochratoxin C showed a stronger suppressive effect on most functions studied. The authors conclude that, because of their immunomodulatory effects in addition to their known …
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