Abstracts From the Literature - Benzene May 2005

TITLE: "A Spreadsheet Program for Modeling Quantitative Structure-pharmacokinetic Relationships for Inhaled Volatile Organics in Humans."

AUTHOR: Beliveau M, Krishnan K.

JOURNAL: SAR QSAR in Environmental Research. 2005 Feb-Apr;16(1-2):63-77.

SUMMARY: The extent and profile of target tissue exposure to toxicants depend upon the pharmacokinetic processes, namely, absorption, distribution, metabolism and excretion. The present study developed a spreadsheet program to simulate the pharmacokinetics of inhaled volatile organic chemicals (VOCs) in humans based on information from molecular structure. The numerical contributions to human Pb and CL were obtained for eleven structural fragments (CH3, CH2, …