Journal Top Ten, Columns-Asbestos, November 2005

TITLE: "Asbestos-Induced Lung Inflammation and Epithelial Cell Proliferation are Altered in Myeloperoxidase-Null Mice"

JOURNAL: Cancer Research. 2005 Nov 1;65(21):9670-7.

AUTHORS: Haegens A, van der Vliet A, Butnor KJ, Heintz N, Taatjes D, Hemenway D, Vacek P, Freeman BA, Hazen SL, Brennan ML, Mossman BT.

SUMMARY: Asbestos fibers are carcinogens causing oxidative stress and inflammation, but the sources and ramifications of oxidant production by asbestos are poorly understood. Here, we show that inhaled chrysotile asbestos fibers cause increased myeloperoxidase activity in bronchoalveolar lavage fluids (BALF) and myeloperoxidase immunoreactivity in epithelial cells …