Journal Top Ten, Columns-Asbestos, January 2005

TITLE: 'Distinct DNA methylation profiles in malignant mesothelioma, lung adenocarcinoma, and non-tumor lung.'

SUMMARY: Malignant mesothelioma (MM), an aggressive cancer strongly associated with asbestos exposure, can be difficult to distinguish from adenocarcinoma of the lung when limited material is available. In an attempt to identify molecular markers for MM and adenocarcinoma, the authors of the study examined the DNA methylation status of 14 loci. The study reveals observations that support the strong potential of methylation markers as tools for accurate diagnosis of neoplasms in and around the lung.

JOURNAL: Lung …