Journal Top Ten - March 2003

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1 TITLE: "Sarcomatoid Mesothelioma and its Histological Mimics: A Comparative Immunohistochemical Study"

SUMMARY: An investigation of the utility of diagnostic immunohistochemistry for distinguishing between sarcomatoid mesothelioma and similar, high-grade sarcoma and pulmonary sarcomatoid carcinoma. The researchers stained 20 mesotheliomas and compared the immunophenotypic profiles with two dozen high-grade sarcomas, and about a dozen pulmonary sarcomatoid carcinomas and 16 epithelioid mesotheliomas. The results indicated that immunohistochemistry plays a more limited role in the differential diagnosis of sarcomatoid tumors compared with epithelioid tumors.

JOURNAL: Histopathology 2003 Mar;42(3):270-9

AUTHORS: D.R. Lucas, H.I. Pass, S.K. Madan, …