Journal Top Ten -- COLUMNS-Asbestos -- February 2007

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TITLE: "Clinico-Pathological Features and Somatic Gene Alterations in Refractory Ceramic Fibre-Induced Murine Mesothelioma Reveal Mineral Fibre-Induced Mesothelioma Identities"

AUTHORS: Andujar P, Lecomte C, Renier A, Fleury-Feith J, Kheuang L, Daubriac J, Janin A, Jaurand MC.

JOURNAL: Carcinogenesis. 2007 Feb 1; [Epub ahead of print]

SUMMARY: While human malignant mesothelioma (HMM) is mainly caused by asbestos exposure, refractory ceramic fibers (RCFs) have been classified as possibly carcinogenic to human on the basis of their biological effects in rodents' lung and pleura, and in cultured cells. These results are the first to identify mutations in RCF-induced mesothelioma. They …